Anakinra suppresses familial Mediterranean fever crises in a colchicine-resistant patient

Neth J Med. 2008 Dec;66(11):489-91.


We describe a 34-year-old male patient suffering from familial Mediterranean fever and experiencing an increase in both the frequency and severity of disease attacks, suggesting resistance to chronic treatment with colchicine. Since no alternative treatment is established, anakinra, an interleukin-1 receptor antagonist, was administered, not daily, as it has been previously reported, but only during crises, with successful outcome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antirheumatic Agents / therapeutic use*
  • Colchicine / pharmacology
  • Colchicine / therapeutic use*
  • Drug Resistance*
  • Familial Mediterranean Fever / drug therapy*
  • Gout Suppressants / pharmacology
  • Gout Suppressants / therapeutic use*
  • Humans
  • Interleukin 1 Receptor Antagonist Protein / therapeutic use*
  • Male


  • Antirheumatic Agents
  • Gout Suppressants
  • Interleukin 1 Receptor Antagonist Protein
  • Colchicine