Regulatory T Cells as Targets for Immunotherapy of Autoimmunity and Inflammation

Inflamm Allergy Drug Targets. 2008 Dec;7(4):217-23. doi: 10.2174/187152808786848360.

Abstract

Regulatory T (Treg) cells are emerging as key players in the regulation of different immune responses, thereby representing potential candidates for therapeutic interventions in a broad variety of immunological disorders. While the reduction or loss in function would be of benefit during the treatment of cancer, induction and/or expansion of Treg cell function might be helpful to interfere with unwanted immune responses in transplantation medicine, during autoimmunity, allergy and inflammation. However, a better understanding of Treg cell biology is a prerequisite to specifically modulate its function during immune responses in vivo. In the present review we will discuss current concepts on different cell types, components and some novel surface receptors expressed by Treg cells, namely Neuropilin-1, CD83 and G protein-coupled receptor 83 which might represent promising targets for the modulation of Treg cell function in human disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Antigens / immunology
  • Antigens, CD / drug effects
  • Autoimmune Diseases / drug therapy*
  • Autoimmune Diseases / immunology
  • Humans
  • Immunoglobulins / drug effects
  • Immunotherapy*
  • Inflammation / drug therapy*
  • Inflammation / immunology
  • Membrane Glycoproteins / drug effects
  • Neuropilin-1 / drug effects
  • Receptors, G-Protein-Coupled / drug effects
  • T-Lymphocytes, Regulatory / drug effects*
  • Transforming Growth Factor beta / physiology
  • Tretinoin / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antigens
  • Antigens, CD
  • CD83 antigen
  • GPR83 protein, human
  • Immunoglobulins
  • Membrane Glycoproteins
  • Receptors, G-Protein-Coupled
  • Transforming Growth Factor beta
  • Neuropilin-1
  • Tretinoin