Small regulatory non-coding RNAs in bacteria: physiology and mechanistic aspects

Biol Cell. 2009 Feb;101(2):117-31. doi: 10.1042/BC20070137.


Regulatory ncRNAs (non-coding RNAs) adjust bacterial physiology in response to environmental cues. ncRNAs can base-pair to mRNAs and change their translation efficiency and/or their stability, or they can bind to proteins and modulate their activity. ncRNAs have been discovered in several species throughout the bacterial kingdom. This review illustrates the diversity of physiological processes and molecular mechanisms where ncRNAs are key regulators.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / genetics*
  • Bacteria / metabolism
  • Bacterial Physiological Phenomena*
  • Carbon / metabolism
  • Gene Expression Regulation, Bacterial*
  • Homeostasis
  • Iron / metabolism
  • Protein Biosynthesis
  • RNA, Bacterial / genetics*
  • RNA, Untranslated / genetics*
  • Transcription, Genetic


  • RNA, Bacterial
  • RNA, Untranslated
  • Carbon
  • Iron