Regulation and function of proinflammatory TH17 cells

Ann N Y Acad Sci. 2008 Nov;1143:188-211. doi: 10.1196/annals.1443.021.


Naïve CD4(+) helper T (TH) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effector cells that are characterized by their distinct cytokine production profiles and immune regulatory functions. In addition to TH1 and TH2 cells, a third subset of effector TH cells has recently been described and termed TH17. Since their identification, TH17 cells have emerged as crucial players in infectious, inflammatory, and autoimmune diseases, and cancer. In this review, we summarize the latest discoveries on the cytokine-mediated regulation and transcriptional programming of TH17 cells and their roles in different immune responses and diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / metabolism
  • Cell Differentiation
  • Cell Lineage
  • Humans
  • Inflammation / immunology*
  • Interleukin-17 / genetics
  • Interleukin-17 / metabolism*
  • Models, Biological
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Phenotype
  • Receptors, Retinoic Acid / immunology
  • Receptors, Retinoic Acid / metabolism
  • Receptors, Thyroid Hormone / immunology
  • Receptors, Thyroid Hormone / metabolism
  • STAT Transcription Factors / immunology
  • STAT Transcription Factors / metabolism
  • T-Lymphocytes, Helper-Inducer / immunology*
  • Transcription, Genetic


  • Interleukin-17
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • RORC protein, human
  • Receptors, Retinoic Acid
  • Receptors, Thyroid Hormone
  • STAT Transcription Factors