Down-regulation of allergic responses in conditions of experimental diabetes: a role for glucocorticoids?

Neuroimmunomodulation. 2009 Jan;16(1):13-8. doi: 10.1159/000179662. Epub 2008 Dec 15.


The prevalence of atopic diseases and diabetes is increasing worldwide, though the co-occurrence of both diseases in the same individual is less frequent than predicted. Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to local and systemic allergen challenges in diabetic conditions. Moreover, dysregulation of the hypothalamic-pituitary-adrenocortical axis and elevated endogenous glucocorticoid levels play a pertinent role in some of the pathological-related processes associated with poorly controlled or uncontrolled diabetes.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Complications / immunology*
  • Diabetes Complications / physiopathology*
  • Down-Regulation / immunology
  • Glucocorticoids / immunology*
  • Humans
  • Hypersensitivity / immunology*
  • Hypersensitivity / physiopathology*
  • Immune Tolerance / immunology*
  • Immunoglobulin E / immunology
  • Mast Cells / immunology
  • Neuroimmunomodulation / immunology
  • Pituitary-Adrenal System / immunology
  • Pituitary-Adrenal System / physiopathology


  • Glucocorticoids
  • Immunoglobulin E