Membrane rafts and caveolae in cardiovascular signaling

Curr Opin Nephrol Hypertens. 2009 Jan;18(1):50-6. doi: 10.1097/MNH.0b013e3283186f82.


Purpose of review: Substantial evidence documents the key role of lipid (membrane) rafts and caveolae as microdomains that concentrate a wide variety of receptors and postreceptor components regulated by hormones, neurotransmitters and growth factors.

Recent findings: Recent data document that these microdomains are important in regulating vascular endothelial and smooth muscle cells and renal epithelial cells, and particularly in signal transduction across the plasma membrane.

Summary: Raft/caveolae domains are cellular regions, including in cardiovascular and renal epithelial cells, which organize a large number of signal transduction components, thereby providing spatially and temporally efficient regulation of cell function.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Physiological Phenomena*
  • Caveolae / physiology*
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiology
  • Epithelial Cells / physiology
  • Humans
  • Kidney / metabolism
  • Membrane Microdomains / physiology*
  • Signal Transduction / physiology*