Diltiazem in the treatment of calcinosis in juvenile dermatomyositis

J Clin Neuromuscul Dis. 2001 Jun;2(4):191-3. doi: 10.1097/00131402-200106000-00005.


Subcutaneous calcifications occur in a variety of diseases, including juvenile dermatomyositis. These calcifications cause disabling symptoms that do not always respond to immunosuppressant therapy. The calcium antagonist diltiazem reduces subcutaneous calcifications in CREST syndrome and in isolated cases of children with dermatomyositis. Our study was performed to determine the effects of diltiazem when used as adjunctive therapy in children with dermatomyositis.