Idiopathic painful sensory neuropathy

J Clin Neuromuscul Dis. 2001 Jun;2(4):211-20. doi: 10.1097/00131402-200106000-00008.


Unexplained painful burning feet are common complaints among the elderly. Conventional elettrodiagnostic testing may be normal or only minimally abnormal and the lack of a universally accepted diagnostic test for small fiber dysfunction has posed a significant impediment to evaluation of these patients. The increasing application of newer diagnostic techniques, including quantitative sensory testing, tests of sudomotor function, and skin biopsy for intrnepidermal nerve fiber quantification, has permitted recognition and characterization of the idiopathic painful sensory neuropathies This article reviews the clinical features, evaluation, and management of this syndrome.