Integrated network analysis platform for protein-protein interactions

Nat Methods. 2009 Jan;6(1):75-7. doi: 10.1038/nmeth.1282. Epub 2008 Dec 14.


There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFbeta signaling, and revealed possible competitive interactors of p53 and c-Jun.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Genetic
  • Humans
  • Protein Binding
  • Protein Interaction Mapping / methods*
  • Proteins / analysis*
  • Proteins / metabolism*
  • Substrate Specificity


  • Proteins