New sequence variants associated with bone mineral density

Nat Genet. 2009 Jan;41(1):15-7. doi: 10.1038/ng.284. Epub 2008 Dec 14.


In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

MeSH terms

  • Base Sequence
  • Bone Density / genetics*
  • Chromosomes, Human, Pair 17 / genetics
  • Female
  • Fractures, Bone / complications
  • Fractures, Bone / genetics
  • Genome-Wide Association Study
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics*
  • Wounds and Injuries / complications
  • Wounds and Injuries / genetics