A sequel to the tale of p25/Cdk5 in neurodegeneration

Neuron. 2008 Dec 10;60(5):731-2. doi: 10.1016/j.neuron.2008.11.020.


p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review
  • Comment

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase 5 / metabolism*
  • Humans
  • Models, Biological
  • Nerve Degeneration / enzymology*


  • Cyclin-Dependent Kinase 5