Boron polylactide nanoparticles exhibiting fluorescence and phosphorescence in aqueous medium

ACS Nano. 2008 Jun;2(6):1252-8. doi: 10.1021/nn7003525.


Difluoroboron dibenzoylmethane-polylactide, BF(2)dbmPLA, a biocompatible polymer-luminophore conjugate was fabricated as nanoparticles. Spherical particles <100 nm in size were generated via nanoprecipitation. Intense blue fluorescence, two-photon absorption, and long-lived room temperature phosphorescence (RTP) are retained in aqueous suspension. The nanoparticles were internalized by cells and visualized by fluorescence microscopy. Luminescent boron biomaterials show potential for imaging and sensing.

Keywords: boron dye; fluorescence; nanoparticles; phosphorescence; poly(lactic acid) (PLA).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Boron Compounds / chemistry*
  • Crystallization / methods
  • Lighting / methods*
  • Luminescent Measurements / methods*
  • Macromolecular Substances / chemistry
  • Materials Testing
  • Molecular Conformation
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure*
  • Nanotechnology / methods
  • Particle Size
  • Polyesters / chemistry*
  • Surface Properties
  • Water / chemistry*


  • Boron Compounds
  • Macromolecular Substances
  • Polyesters
  • Water
  • poly(lactide)