The receptor basis of sweet taste in mammals

Results Probl Cell Differ. 2009:47:187-202. doi: 10.1007/400_2008_2.


The taste of sweeteners is hedonically pleasing, suggests high caloric value in food, and contributes to increased intake. In recent years, many of the molecular mechanisms underlying the detection of sweeteners have been elucidated. Of particular note is the identification of the sweet taste receptor, the heteromeric G-protein-coupled receptor T1R2:T1R3, which responds to a vast array of chemically diverse natural and artificial sweeteners. In this chapter, we discuss some of the mechanisms underlying the detection of sweeteners by mammals, with a particular focus on the function and role of the T1R2:T1R3 receptor in these processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Glucose / metabolism
  • Glucose / pharmacology
  • Humans
  • Mammals / metabolism
  • Mammals / physiology*
  • Receptors, G-Protein-Coupled / metabolism
  • Receptors, G-Protein-Coupled / physiology*
  • Sucrose / metabolism
  • Sucrose / pharmacology
  • Sweetening Agents / metabolism*
  • Sweetening Agents / pharmacology
  • Taste Buds / drug effects
  • Taste Buds / metabolism
  • Taste Buds / physiology
  • Taste Perception / drug effects
  • Taste Perception / physiology*


  • Receptors, G-Protein-Coupled
  • Sweetening Agents
  • taste receptors, type 1
  • Sucrose
  • Glucose