Treatment-associated subsequent neoplasms among long-term survivors of childhood cancer: the experience of the Childhood Cancer Survivor Study

Pediatr Radiol. 2009 Feb;39 Suppl 1(Suppl 1):S32-7. doi: 10.1007/s00247-008-1066-8. Epub 2008 Dec 16.


With improvements in survival among individuals diagnosed and treated for cancer there is an increasing recognition of the risk of long-term adverse effects of therapy. Second neoplasms represent one of the more serious late effects of treatment and are associated with a substantial level of morbidity and mortality. Survivors of childhood cancers, because of their potential longevity, are at particular risk for this adverse outcome. The Childhood Cancer Survivor Study is a large cohort consisting of adult survivors of childhood cancer diagnosed and treated between 1970 and 1986. The CCSS has provided important data to quantify radiation-associated risk for subsequent cancers including neoplasms of the breast, thyroid and central nervous system.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adult
  • Breast Neoplasms / etiology
  • Central Nervous System Neoplasms / etiology
  • Child
  • Humans
  • Neoplasms, Radiation-Induced / etiology*
  • Neoplasms, Second Primary / chemically induced
  • Neoplasms, Second Primary / etiology*
  • Risk Factors
  • Thyroid Neoplasms / etiology