Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial

Nutr Res. 2008 Jan;28(1):1-5. doi: 10.1016/j.nutres.2007.10.001.


Stress plays an important role in the development of symptoms contributing to disease. Stress induces various disorders with gastrointestinal, physical, and psychological symptoms. Probiotics can help regulate or modulate gastrointestinal functions. The aim of the present study was to investigate the effects of a probiotic preparation (Probio-Stick) on stress-induced symptoms in volunteers. A double-blind, placebo-controlled, randomized study was conducted on volunteers with symptoms of stress. Subjects received a probiotic (Probio-Stick; Lallemand SAS, Saint-Simon, France) containing Lactobacillus acidophilus Rosell-52 and Bifidobacterium longum Rosell-175 (3 x 10(9) colony-forming units per sachet stick) or a sensorially identical placebo without probiotics during a 3-week period. The consumption of probiotics significantly reduced 2 stress-induced gastrointestinal symptoms (abdominal pain and nausea/vomiting) for intention-to-treat or per-protocol populations. In contrast, the probiotics did not significantly modify the other physical and psychological symptoms and sleep problems induced by stressful life events for intention-to-treat or per-protocol populations. The results indicate that Probio-Stick can provide a beneficial effect on the gastrointestinal symptoms experienced by individuals affected by chronic stress.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Pain / drug therapy
  • Adolescent
  • Adult
  • Bifidobacterium / growth & development
  • Bifidobacterium / physiology
  • Colony Count, Microbial
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Gastrointestinal Diseases / drug therapy*
  • Gastrointestinal Diseases / psychology
  • Humans
  • Lactobacillus acidophilus / growth & development
  • Lactobacillus acidophilus / physiology
  • Male
  • Middle Aged
  • Nausea / drug therapy
  • Placebos
  • Probiotics / pharmacology*
  • Probiotics / therapeutic use
  • Quality of Life*
  • Stress, Psychological*
  • Treatment Outcome
  • Young Adult


  • Placebos