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Review
. 2008 Jul;12(3):191-3.
doi: 10.1016/j.jbmt.2008.03.005. Epub 2008 May 23.

Fibroblast Mechanics in Three-Dimensional Collagen Matrices

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Free PMC article
Review

Fibroblast Mechanics in Three-Dimensional Collagen Matrices

Frederick Grinnell. J Bodyw Mov Ther. .
Free PMC article

Abstract

Fascia provides mechanical support and frameworks for the other tissues of the body. Type 1 collagen is the major protein component of fascia, and fibroblasts are the cell type primarily responsible for its biosynthesis and remodeling. Research on fibroblasts interacting with collagen matrices provides new insights regarding how cell-matrix tension state and growth factor specificity regulate cell migration and matrix remodeling.

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Figure 1
Figure 1
Fibroblast mechanics in three dimensional collagen matrices

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