Analysis of mutations in father-son pairs with 17 Y-STR loci

Amy E Decker; Margaret C Kline; Janette W Redman; Thomas M Reid; John M Butler

doi:10.1016/j.fsigen.2007.08.016

Analysis of mutations in father-son pairs with 17 Y-STR loci

Forensic Sci Int Genet. 2008 Jun;2(3):e31-5. doi: 10.1016/j.fsigen.2007.08.016. Epub 2007 Nov 1.

Authors

Amy E Decker¹, Margaret C Kline, Janette W Redman, Thomas M Reid, John M Butler

Affiliation

¹ Biochemical Science Division, National Institute of Sciences and Technology, Gaithersburg, MD 20899-8311, USA. amy.decker@nist.gov

PMID: 19083812
DOI: 10.1016/j.fsigen.2007.08.016

Abstract

We have examined 389 father/son sample pairs from U.S. Caucasians, African Americans, Hispanics and Asians using the 17 Y-STR loci in the Yfilertrade mark kit and observed a total of 24 differences between father and son. Thirteen mutations resulted in the gain of a repeat in the son and 11 resulted in a loss of a repeat. All samples resulted in single repeat mutations except one sample which contained a two repeat loss at Y-GATA-H4. Furthermore, two different sample pairs were found to have two mutations. An African American sample pair had a mutation at DYS458 and a second at DYS635 and an Asian sample pair had mutations at DYS439 and Y-GATA-H4.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alleles
Asian People / genetics
Black or African American / genetics
Child
Chromosomes, Human, Y*
DNA Fingerprinting / methods
Fathers*
Gene Deletion
Gene Duplication
Genetics, Population
Haplotypes
Hispanic or Latino / genetics
Humans
Male
Microsatellite Repeats*
Mutation*
Nuclear Family*
Polymerase Chain Reaction
United States
White People / genetics