Analysis of mutations in father-son pairs with 17 Y-STR loci

Forensic Sci Int Genet. 2008 Jun;2(3):e31-5. doi: 10.1016/j.fsigen.2007.08.016. Epub 2007 Nov 1.


We have examined 389 father/son sample pairs from U.S. Caucasians, African Americans, Hispanics and Asians using the 17 Y-STR loci in the Yfilertrade mark kit and observed a total of 24 differences between father and son. Thirteen mutations resulted in the gain of a repeat in the son and 11 resulted in a loss of a repeat. All samples resulted in single repeat mutations except one sample which contained a two repeat loss at Y-GATA-H4. Furthermore, two different sample pairs were found to have two mutations. An African American sample pair had a mutation at DYS458 and a second at DYS635 and an Asian sample pair had mutations at DYS439 and Y-GATA-H4.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Asian People / genetics
  • Black or African American / genetics
  • Child
  • Chromosomes, Human, Y*
  • DNA Fingerprinting / methods
  • Fathers*
  • Gene Deletion
  • Gene Duplication
  • Genetics, Population
  • Haplotypes
  • Hispanic or Latino / genetics
  • Humans
  • Male
  • Microsatellite Repeats*
  • Mutation*
  • Nuclear Family*
  • Polymerase Chain Reaction
  • United States
  • White People / genetics