Genetic and developmental basis for urinary tract obstruction

Pediatr Nephrol. 2009 Sep;24(9):1621-32. doi: 10.1007/s00467-008-1072-y. Epub 2008 Dec 16.


Urinary tract obstruction results in obstructive nephropathy and uropathy. It is the most frequent cause of renal failure in infants and children. In the past two decades studies of transgenic models and humans have greatly enhanced our understanding of the genetic factors and developmental processes important in urinary tract obstruction. The emerging picture is that development of the urinary tract requires precise integration of a variety of progenitor cell populations of different embryonic origins. Such integration is controlled by an intricate signaling network that undergoes dynamic changes as the embryo develops. Most congenital forms of urinary tract obstruction result from the disruption of diverse factors and genetic pathways involved in these processes, especially in the morphogenesis of the urinary conduit or the functional aspects of the pyeloureteral peristaltic machinery.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Child
  • Disease Models, Animal
  • Embryonic Development
  • Gene Expression Regulation, Developmental
  • Humans
  • Hydronephrosis / embryology
  • Hydronephrosis / genetics
  • Hydronephrosis / pathology
  • Infant
  • Male
  • Mice
  • Mice, Transgenic
  • Mutation
  • Ureteral Obstruction / embryology
  • Ureteral Obstruction / genetics
  • Ureteral Obstruction / pathology
  • Urethral Obstruction / embryology
  • Urethral Obstruction / genetics
  • Urethral Obstruction / pathology
  • Urinary Tract / abnormalities*
  • Urinary Tract / pathology
  • Urologic Diseases / embryology*
  • Urologic Diseases / genetics*
  • Urologic Diseases / pathology