Gross Placental Measures and Childhood Growth

J Matern Fetal Neonatal Med. 2009 Jan;22(1):13-23. doi: 10.1080/14767050802415728.

Abstract

Objectives: We hypothesised that the gross placental measures would be positively associated with childhood growth.

Methods: We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7.

Results: Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (beta = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (beta = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: beta = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005).

Conclusions: Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Birth Weight / physiology
  • Body Mass Index
  • Child
  • Child Development / physiology*
  • Child, Preschool
  • Ethnic Groups / statistics & numerical data
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Male
  • Maternal-Fetal Relations / ethnology
  • Organ Size / physiology
  • Placentation*
  • Pregnancy
  • Social Class
  • Young Adult