The effect of Equisetum arvense L. (Equisetaceae) in histological changes of pancreatic beta-cells in streptozotocin-induced diabetic in rats

Pak J Biol Sci. 2007 Dec 1;10(23):4236-40. doi: 10.3923/pjbs.2007.4236.4240.

Abstract

In view of alleged, the methanolic extract of Equisetum arvense was analysed for its antidiabetic activity in streptozotocin-induced diabetic rats. The blood glucose lowering activity of the methanolic extract was determined in streptozotocin-induced (50 mg kg(-1), i.p.; dissolved in normal saline) diabetic rats, after oral administration in doses of 50 and 250 mg kg(-1) daily for 5 weeks. The data was compare statistically using one-way ANOVA tukey test. The results showed methanolic extract of Equisetum arvense produced a significant antidiabetic activity at doses 50 and 50 mg kg(-1)/b.wt. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic extract which were earlier, necrosed by streptozotocin.

MeSH terms

  • Analysis of Variance
  • Animals
  • Diabetes Mellitus, Experimental / pathology*
  • Equisetum / chemistry*
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / pathology
  • Male
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Streptozocin

Substances

  • Plant Extracts
  • Streptozocin