The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer

BMC Cancer. 2008 Dec 16;8:369. doi: 10.1186/1471-2407-8-369.


Background: The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene. Whereas it is known that c-myc alterations play a completely different role in various carcinomas of the urogenital tract, the relevance of FBPs is unclear.

Methods: FBP1, FBP3 and c-myc expression was studied in 105 renal cell, 95 prostate and 112 urinary bladder carcinomas by immunohistochemistry using tissue microarrays.

Results: High rates of FBP1 and FBP3 expression were observed in all cancer types. There was a concomitant up-regulation of FBP1 and FBP3 in renal cell and prostate carcinomas (p < 0.001 both). C-myc expression was detectable in 21% of prostate, 30% of renal and 34% of urothelial carcinomas. Interestingly, strong FBP1 and FBP3 expression was associated with c-myc up-regulation in clear cell renal cell carcinomas (p < 0.001 and 0.09 resp.), but not in bladder or prostate cancer.

Conclusion: The correlation between FBP1/FBP3, c-myc and high proliferation rate in renal cell carcinoma provides strong in vivo support for the suggested role of FBP1 and FBP3 as activators of c-myc. The frequent up-regulation of FBP1 and FBP3 in urothelial and prostate carcinoma suggests that FBPs also have an important function in gene regulation of these tumors.

MeSH terms

  • Chi-Square Distribution
  • DNA Helicases / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation, Neoplastic / physiology*
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms / metabolism
  • Kidney Neoplasms / pathology
  • Male
  • Middle Aged
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / pathology
  • RNA-Binding Proteins
  • Statistics, Nonparametric
  • Tissue Array Analysis
  • Transcription Factors / metabolism*
  • Urinary Bladder Neoplasms / metabolism
  • Urinary Bladder Neoplasms / pathology
  • Urogenital Neoplasms / metabolism*
  • Urogenital Neoplasms / pathology


  • DNA-Binding Proteins
  • FUBP1 protein, human
  • FUBP3 protein, human
  • MYCBP protein, human
  • RNA-Binding Proteins
  • Transcription Factors
  • DNA Helicases