A short history of cGMP, guanylyl cyclases, and cGMP-dependent protein kinases

Handb Exp Pharmacol. 2009;(191):1-14. doi: 10.1007/978-3-540-68964-5_1.

Abstract

Here, we review the early studies on cGMP, guanylyl cyclases, and cGMP-dependent protein kinases to facilitate understanding of development of this exciting but complex field of research encompassing pharmacology, biochemistry, physiology, and molecular biology of these important regulatory molecules.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Cyclic GMP / history
  • Cyclic GMP / metabolism*
  • Cyclic GMP-Dependent Protein Kinases / history
  • Cyclic GMP-Dependent Protein Kinases / metabolism*
  • Guanylate Cyclase / history
  • Guanylate Cyclase / metabolism*
  • History, 20th Century
  • Humans
  • Protein Conformation
  • Protein Isoforms
  • Signal Transduction

Substances

  • Protein Isoforms
  • Cyclic GMP-Dependent Protein Kinases
  • Guanylate Cyclase
  • Cyclic GMP