Fifty-gigahertz microwave exposure effect of radiations on rat brain

Appl Biochem Biotechnol. 2009 Jul;158(1):126-39. doi: 10.1007/s12010-008-8469-8. Epub 2008 Dec 17.

Abstract

The object of this study is to investigate the effects of 50-GHz microwave radiation on the brain of Wistar rats. Male rats of the Wistar strain were used in the study. Animals of 60-day age were divided into two groups-group 1, sham-exposed, and group 2, experimental (microwave-exposed). The rats were housed in a temperature-controlled room (25 degrees C) with constant humidity (40-50%) and received food and water ad libitum. During exposure, rats were placed in Plexiglas cages with drilled ventilation holes and kept in an anechoic chamber. The animals were exposed for 2 h a day for 45 days continuously at a power level of 0.86 microW/cm(2) with nominal specific absorption rate 8.0 x 10(-4) w/kg. After the exposure period, the rats were killed and homogenized, and protein kinase C (PKC), DNA double-strand break, and antioxidant enzyme activity [superoxides dismutase (SOD), catalase, and glutathione peroxidase (GPx)] were estimated in the whole brain. Result shows that the chronic exposure to these radiations causes DNA double-strand break (head and tail length, intensity and tail migration) and a significant decrease in GPx and SOD activity (p = or<0.05) in brain cells, whereas catalase activity shows significant increase in the exposed group of brain samples as compared with control (p = or<0.001). In addition to these, PKC decreased significantly in whole brain and hippocampus (p < 0.05). All data are expressed as mean +/- standard deviation. We conclude that these radiations can have a significant effect on the whole brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Brain / cytology
  • Brain / enzymology
  • Brain / metabolism
  • Brain / radiation effects*
  • DNA Breaks, Double-Stranded / radiation effects
  • Male
  • Microwaves / adverse effects*
  • Protein Kinase C / metabolism
  • Rats
  • Rats, Wistar

Substances

  • Antioxidants
  • Protein Kinase C