Use of diazepam for hyperemesis gravidarum

J Matern Fetal Neonatal Med. 2009 Apr;22(4):353-6. doi: 10.1080/14767050802464528.


Objective: To evaluate the efficacy and safety of intravenous (IV) fluid and diazepam therapy compared with the IV-fluid only therapy for the resistant hyperemesis gravidarum (HG) cases.

Methods: Medical records of 74 HG cases who were refractory to standard management were reviewed. All patients hospitalised were administered IV fluid and multivitamin combination as the first-step therapy. Patients who were refractory to first-step therapy were given IV fluid (Group 1, n = 43) or IV fluid and diazepam (Group 2, n = 31) depending on the patients' desire. Groups were matched for demographic characteristics, rehospitalisation requirement, patient satisfaction and neonatal outcomes.

Results: Thirteen of the 74 patients were excluded from the study because of unknown maternal and fetal outcome. The mean gestational age was 10.4 +/- 2.4 year. Age, parity, body mass index and educational level were similar between the two groups. Mean diazepam dose was 62.8 +/- 24.5 mg (range 40-160) in Group 2 (n = 31). The number of hospitalisation was significantly lower, and patient satisfaction was significantly higher in Group 2. There were no differences for the obstetrics outcomes between the groups.

Conclusions: The addition of diazepam to IV fluids was associated with less hospitalisation in women with hyperemesis gravidarum. Safety of diazepam therapy in early pregnancy deserves further study.

MeSH terms

  • Adult
  • Antiemetics / administration & dosage*
  • Antiemetics / adverse effects
  • Diazepam / administration & dosage*
  • Diazepam / adverse effects
  • Female
  • Glucose / administration & dosage
  • Humans
  • Hyperemesis Gravidarum / drug therapy*
  • Infusions, Intravenous
  • Isotonic Solutions / administration & dosage
  • Male
  • Pregnancy
  • Ringer's Lactate
  • Sodium Chloride / administration & dosage
  • Vitamins / administration & dosage
  • Young Adult


  • Antiemetics
  • Isotonic Solutions
  • Ringer's Lactate
  • Vitamins
  • Sodium Chloride
  • Glucose
  • Diazepam