The effect of ginger extract on blood urea nitrogen and creatinine in mice

Pak J Biol Sci. 2007 Sep 1;10(17):2968-71. doi: 10.3923/pjbs.2007.2968.2971.


The present study is going to determine whether ginger has positive or negative effects of kidney. A hydro alcoholic extract of ginger was administered intraperitoneally (IP) every 48 h to male mice for a period of 20 days. Control group received saline containing equal volume of ethanol. Blood Urea Nitrogen (BUN) and creatinine were measured spectrophotometrically. Administration of ginger extract markedly decreased the BUN concentrations in experimental mice in a non linear fashion with regard to the administrated dosages. However, little changes were observed in the levels of creatinine in these animals as compared with control group. It is concluded that ginger may have a beneficial effect for removal of urea from plasma and it may be considered as a therapeutic herb to manage renal function in patient with uremia.

MeSH terms

  • Animals
  • Blood Urea Nitrogen*
  • Creatinine / metabolism*
  • Dose-Response Relationship, Drug
  • Ethanol / pharmacology
  • Male
  • Mice
  • Phytotherapy / methods
  • Plant Extracts / pharmacology*
  • Salts / pharmacology
  • Spectrophotometry / methods
  • Uremia
  • Zingiber officinale / metabolism*


  • Plant Extracts
  • Salts
  • Ethanol
  • Creatinine