Reciprocal cellular and humoral immune responses in bovine tuberculosis

Res Vet Sci. 1991 May;50(3):365-7. doi: 10.1016/0034-5288(91)90143-c.


A sandwich ELISA for the detection of gamma interferon showed higher sensitivity and specificity than an indirect ELISA for mycobacterial antibodies in the diagnosis of bovine tuberculosis. Circumstantial evidence of an inverse relationship between cellular and humoral immune responses to Mycobacterium bovis was found in cattle with natural infection.

MeSH terms

  • Animals
  • Antibodies, Bacterial / biosynthesis*
  • Antibodies, Bacterial / blood
  • Cattle
  • Enzyme-Linked Immunosorbent Assay
  • Immunity, Cellular
  • Interferon-gamma / analysis*
  • Mycobacterium bovis / immunology*
  • Predictive Value of Tests
  • Tuberculin / immunology
  • Tuberculosis, Bovine / diagnosis
  • Tuberculosis, Bovine / immunology*


  • Antibodies, Bacterial
  • Tuberculin
  • Interferon-gamma