Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species

Liza S Fernandez; Malcolm S Buchanan; Anthony R Carroll; Yun Jiang Feng; Ronald J Quinn; Vicky M Avery

doi:10.1021/ol802506n

Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species

Org Lett. 2009 Jan 15;11(2):329-32. doi: 10.1021/ol802506n.

Authors

Liza S Fernandez¹, Malcolm S Buchanan, Anthony R Carroll, Yun Jiang Feng, Ronald J Quinn, Vicky M Avery

Affiliation

¹ Eskitis Institute, Griffith University, Brisbane, QLD 4111 Australia.

PMID: 19090698
DOI: 10.1021/ol802506n

Abstract

With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC(50) values between 0.15-1.42 microM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification*
Antimalarials / pharmacology*
Drug Evaluation, Preclinical
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology*
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Parasites / drug effects
Parasites / growth & development
Rutaceae / chemistry*

Substances

Antimalarials
Indole Alkaloids
flinderole A
flinderole B
flinderole C