Neurosarcoidosis: clinical features, diagnosis, and management

Am J Ther. 2013 May-Jun;20(3):292-9. doi: 10.1097/MJT.0b013e31818637ef.


Sarcoidosis is a multisystemic granulomatous disease, which uncommonly affects nervous system. However, when present, it may affect both central and peripheral nervous systems and potentially mimics other chronic diseases of the nervous system. Pathogenesis of neurosarcoidosis remains largely unknown, and its diagnosis and management pose serious challenges to clinicians. Early diagnosis and aggressive treatment of neurosarcoidosis are necessary to produce satisfactory clinical outcomes. This review discusses clinical manifestations, current diagnostic studies, and currently available modalities for management of neurosarcoidosis.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Central Nervous System Diseases* / diagnosis
  • Central Nervous System Diseases* / physiopathology
  • Central Nervous System Diseases* / therapy
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Early Diagnosis
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Neurosurgical Procedures
  • Prognosis
  • Sarcoidosis* / diagnosis
  • Sarcoidosis* / physiopathology
  • Sarcoidosis* / therapy


  • Anti-Inflammatory Agents
  • Immunosuppressive Agents

Supplementary concepts

  • Neurosarcoidosis