Observational study: Matricaria chamomilla may improve some symptoms of attention-deficit hyperactivity disorder

Phytomedicine. 2009 Apr;16(4):284-6. doi: 10.1016/j.phymed.2008.10.006. Epub 2008 Dec 20.


Objective: Noradrenaline and serotonin reuptake inhibitors have been proven to be effective in some cases of ADHD. In this open trial, Matricaria chamomilla, a serotonin and noradrealine reuptake inhibitor, actually used as an antidepressant, has been checked for this indication.

Method: Three 14-16-year-old male psychiatric outpatients, diagnosed with attention-deficit disorder (ADHD) have been rated at baseline and while taking Matricaria chamomilla to determine its efficacy as a treatment for ADHD. Improvement was valuated using comparisons of Conners' parent ratings.

Results: Patients' mean scores improved for Conners' hyperactivity, inattention and immaturity factors.

Conclusions: Although the sample size is very small and therefore generalization is very difficult, this observation indicates that Matricaria chamomilla might be a slightly effective treatment also for ADHD.

MeSH terms

  • Adolescent
  • Adrenergic Antagonists / therapeutic use
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Humans
  • Male
  • Matricaria*
  • Monocyclic Sesquiterpenes
  • Observation
  • Oils, Volatile / therapeutic use*
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Serotonin Uptake Inhibitors / therapeutic use
  • Sesquiterpenes / therapeutic use*


  • Adrenergic Antagonists
  • Monocyclic Sesquiterpenes
  • Oils, Volatile
  • Plant Extracts
  • Serotonin Uptake Inhibitors
  • Sesquiterpenes
  • bisabolol