Abstract
In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-sensitive properties of the new nanocarriers and in vitro cytotoxicity of the doxorubicin-nanocarrier are presented as well as preliminary data regarding their toxicity and tumor targeting potential in nude mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Biocompatible Materials / chemistry
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Carbocyanines / administration & dosage
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Carbocyanines / chemistry*
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Dendritic Cells / metabolism*
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Doxorubicin / administration & dosage
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Doxorubicin / chemistry*
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Drug Carriers*
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Female
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Glycerol / chemistry
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Hydrogen-Ion Concentration
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Inhibitory Concentration 50
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Mice
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Mice, Nude
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Nanoparticles / chemistry
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Nanotechnology / methods*
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Polymers / chemistry
Substances
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Antineoplastic Agents
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Biocompatible Materials
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Carbocyanines
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Drug Carriers
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Polymers
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indotricarbocyanine
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polyglycerol
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Doxorubicin
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Glycerol