The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure

Cell Cycle. 2008 Dec 15;7(24):3935-42. doi: 10.4161/cc.7.24.7397. Epub 2008 Dec 13.


In the nematode Caenorhabditis elegans, the let-7 microRNA (miRNA) controls the timing of key developmental events and terminal differentiation in part by directly regulating lin-41. C. elegans lin-41 mutants display precocious cell cycle exit and terminal differentiation of epidermal skin cells. lin-41 orthologues are found in more complex organisms including both mice and humans, but their roles are not known. We generated Mlin41 mouse mutants to ascertain a functional role for Mlin41. Strong loss of function Mlin41 gene-trap mutants demonstrated a striking neural tube closure defect during development, and embryonic lethality. Like C. elegans lin-41, Mlin41 also appears to be regulated by the let-7 and mir-125 miRNAs. Since Mlin41 is required for neural tube closure and survival it points to human lin-41 (HLIN41/TRIM71) as a potential human development and disease gene.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Genes, Lethal
  • HeLa Cells
  • Humans
  • Mice
  • Mice, Knockout
  • MicroRNAs / metabolism*
  • Mutation
  • Neural Tube / embryology*
  • Transcription Factors / genetics*


  • LIN-41 protein, mouse
  • MicroRNAs
  • Transcription Factors
  • mirnlet7 microRNA, human