Osteosarcoma: Conventional treatment vs. gene therapy

Cancer Biol Ther. 2009 Jan;8(2):106-17. doi: 10.4161/cbt.8.2.7385. Epub 2009 Feb 12.


Osteosarcoma (OS) remains the most common primary malignant bone cancer affecting children and adolescents. Majority of patients are subjected to surgery and chemotherapy with limited alternatives to consider. However, with increasing knowledge of the molecular pathogenesis of OS, advancements in OS therapy research fields have developed potential agents for a more targeted and localised approach to treatment. Thus, this review attempts to examine some common treatment strategies (surgery, radiotherapy and chemotherapy) employed clinically as well as recent developments in newer experimental therapy methods (gene therapy) which might potentially benefit patients.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Bone Neoplasms / drug therapy*
  • Bone Neoplasms / pathology
  • Bone Neoplasms / radiotherapy
  • Bone Neoplasms / surgery
  • Bone Neoplasms / therapy*
  • Chemotherapy, Adjuvant
  • Child
  • Genetic Therapy*
  • Humans
  • Osteosarcoma / drug therapy*
  • Osteosarcoma / pathology
  • Osteosarcoma / radiotherapy
  • Osteosarcoma / surgery
  • Osteosarcoma / therapy*
  • Radiotherapy, Adjuvant
  • Treatment Outcome