Serum Soluble CD8 Molecule Is a Marker of CD8 T-cell Activation in HIV-1 Disease

AIDS. 1991 Jul;5(7):805-12. doi: 10.1097/00002030-199107000-00003.

Abstract

To characterize CD8 T-cell activation during HIV-1 infection we measured serum soluble CD8 (sCD8) levels longitudinally in seroconverters and in individuals with established HIV infection who were in different stages of illness. CD8 T-cell activation occurs very early in HIV infection. Serum sCD8 levels were elevated in 91.5% of the first seropositive samples in seroconverters. Furthermore, CD8 T-cell activation persists throughout HIV infection. sCD8 predicted the occurrence of AIDS in HIV-seropositive individuals and so the addition of serum sCD8 levels to CD4 T-cell measurements increased the power in predicting the onset of AIDS. The serum level of sCD8 was particularly relevant to the prediction of subsequent CD4 T-cell fall relatively early in infection, for example, in the 3 years after seroconversion. However, later in HIV infection, for example within 2 years prior to development of AIDS, sCD8 levels were less predictive. sCD8 correlated with levels of beta 2-microglobulin and neopterin, which reflect activation of cell types other than CD8. Thus, serum sCD8 level can be a useful marker of specific CD8 T-cell activation, and is an independent predictor of prognosis in HIV infection.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / physiopathology
  • Antigens, Differentiation, T-Lymphocyte / blood*
  • Biomarkers / blood
  • CD8 Antigens
  • Cohort Studies
  • HIV Infections / immunology*
  • HIV Seropositivity / immunology
  • HIV-1*
  • Lymphocyte Activation*
  • Lymphocyte Subsets / immunology*
  • Solubility

Substances

  • Antigens, Differentiation, T-Lymphocyte
  • Biomarkers
  • CD8 Antigens