Th2 cells as targets for therapeutic intervention in allergic bronchial asthma

Expert Rev Mol Diagn. 2009 Jan;9(1):85-100. doi: 10.1586/14737159.9.1.85.

Abstract

Th2 cells play a central role in the pathogenesis of allergic bronchial asthma, since each of their characteristic cytokines such as IL-4, IL-5, IL-9 and IL-13 contributes to hallmarks of this disease, including airway eosinophilia, increased mucus production, production of allergen-specific IgE and development of airway hyper-responsiveness. Therefore, these cells are predisposed as target cells for therapeutic intervention. Experimental approaches targeted Th2-type effector cytokines, Th2-cell recruitment and Th2-cell development. Another strategy uses the immunomodulatory potential of tolerance-inducing cytokines such as IL-10 or of cytokines such as IL-12, IL-18 and IFN-gamma that are able to induce a counterbalancing Th1 immune response.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Asthma / immunology*
  • Asthma / therapy*
  • Cell Movement / immunology
  • Humans
  • Hypersensitivity / immunology
  • Hypersensitivity / therapy
  • Immunologic Factors / therapeutic use
  • Th2 Cells / cytology
  • Th2 Cells / drug effects
  • Th2 Cells / immunology*

Substances

  • Anti-Inflammatory Agents
  • Immunologic Factors