Sigma-1 receptor knockout mice display a depressive-like phenotype

Behav Brain Res. 2009 Mar 17;198(2):472-6. doi: 10.1016/j.bbr.2008.11.036. Epub 2008 Nov 30.

Abstract

Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anxiety / physiopathology
  • Anxiety / psychology*
  • Depression / physiopathology
  • Depression / psychology*
  • Exploratory Behavior / physiology
  • Genotype
  • Immobilization / psychology*
  • Maze Learning / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity* / physiology
  • Mutation
  • Phenotype
  • Polymerase Chain Reaction
  • Receptors, sigma / deficiency
  • Receptors, sigma / genetics*
  • Receptors, sigma / physiology*
  • Swimming

Substances

  • Receptors, sigma
  • sigma-1 receptor