Estimation of standard liver volume for liver transplantation in the Chinese population

Transplant Proc. 2008 Dec;40(10):3536-40. doi: 10.1016/j.transproceed.2008.07.135.


Introduction: The accurate assessment of standard liver volume (SLV) is necessary for the safety of both the donor and the recipient in living donor liver transplantation. However, the accuracy of SLV formulas relates to cohorts or races. This study examined the accuracy of a simple linear formula versus previous formulas of SLV for Chinese adults.

Methods: Among 112 patients with normal liver, we created a new formula for SLV with stepwise regression analysis using the following variables: age, gender, body weight, body height, body mass index, and body surface area. The agreement between the actual liver volume (LV) and calculated LV using various formulas was prospectively evaluated among 63 living donors by paired-sample student's t-test and Lin's concordance correlation coefficient.

Results: A new formula was developed SLV (mL) = 949.7 x BSA (m(2)) - 48.3 x age - 247.4 where age was counted as 1 for those <40, 2 if 41-60, and 3 if >60 years old. The calculated LV using our formula showed no significant difference from the actual LV using the paired-samples student's t-test (P = .653). Lin's concordance correlation coefficient showed substantial agreement between estimated LV using our formula and actual LV. Furthermore, this study also observed an almost perfect agreement between our formula and the Yoshizumi et al formula.

Conclusion: Our formula, which accurately estimated LV among Chinese adults, may be applicable to adults of other ethnicitis.

MeSH terms

  • Adult
  • Asian Continental Ancestry Group
  • Body Mass Index
  • Body Size
  • Body Surface Area
  • China
  • Female
  • Humans
  • Liver / anatomy & histology*
  • Liver Transplantation / methods*
  • Living Donors*
  • Male
  • Middle Aged
  • Reference Values
  • Regression Analysis