Age-related oxidative stress modulation by smoking habit and obesity

Clin Biochem. 2009 May;42(7-8):739-41. doi: 10.1016/j.clinbiochem.2008.11.017. Epub 2008 Dec 11.


Objective: To evaluate whether obesity and smoking habit may accelerate the age-related increase of oxidative stress.

Methods: The Oxidative-INDEX, a score reflecting both oxidative and antioxidant counterparts, was estimated in 179 subjects (50 males, aged 16-79 years).

Results: Oxidative stress results were elevated in obese and smoker subjects. Adjusted logistic regression analysis indicated obesity and smoking as independent variables for elevated Oxidative-INDEX (odds ratio=4.8 and 3.1, respectively). Oxidative-INDEX steadily rises at a mean rate of 5.3% (0.017 AU) per year in the overall population, showing twice and three times higher annual rate increase in smokers and obese subjects.

Conclusion: Our results suggest the pro-ageing effects of cigarette smoking and obesity by a more rapid and sharp elevation of the oxidative stress status.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging / physiology*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Obesity / physiopathology*
  • Oxidative Stress / drug effects*
  • Oxidative Stress / physiology*
  • Smoking / adverse effects*
  • Young Adult