Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala

Planta Med. 2009 Mar;75(4):335-7. doi: 10.1055/s-0028-1112215. Epub 2008 Dec 19.

Abstract

Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterase Inhibitors / pharmacology*
  • Dose-Response Relationship, Drug
  • Malvaceae / chemistry*
  • Molecular Structure
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology*
  • Plant Leaves / chemistry*
  • Quinolines / chemistry
  • Quinolines / pharmacology*

Substances

  • Cholinesterase Inhibitors
  • Peptides, Cyclic
  • Quinolines
  • waltherine
  • waltherione-A
  • waltherione-B
  • Acetylcholinesterase