Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions

Angew Chem Int Ed Engl. 2009;48(4):811-4. doi: 10.1002/anie.200804695.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Aniline Compounds / chemistry*
  • Catalytic Domain
  • Cations / chemistry
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemistry
  • Factor Xa / chemistry*
  • Factor Xa Inhibitors
  • Ligands
  • Quaternary Ammonium Compounds / chemistry*
  • Thermodynamics

Substances

  • Aniline Compounds
  • Cations
  • Enzyme Inhibitors
  • Factor Xa Inhibitors
  • Ligands
  • Quaternary Ammonium Compounds
  • Factor Xa