Bacterial Multidrug Transport Through the Lens of the Major Facilitator Superfamily

Biochim Biophys Acta. 2009 May;1794(5):738-47. doi: 10.1016/j.bbapap.2008.11.020. Epub 2008 Dec 7.

Abstract

Multidrug transporters are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell. Through this function, they render cells resistant to multiple drugs. These transporters are found in many different families of transport proteins, of which the largest is the major facilitator superfamily. Multidrug transporters from this family are highly represented in bacteria and studies of them have provided important insight into the mechanism underlying multidrug transport. This review summarizes the work carried out on these interesting proteins and underscores the differences and similarities to other transport systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Drug Resistance, Bacterial / physiology
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Membrane Transport Proteins / physiology*
  • Models, Molecular
  • Multidrug Resistance-Associated Proteins / physiology*
  • Static Electricity

Substances

  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Proteins