Factors contributing to increased serum urate in postmenopausal Japanese females

Climacteric. 2009 Apr;12(2):146-52. doi: 10.1080/13697130802607719.


Objective: The level of serum urate is generally elevated in postmenopausal individuals. In addition to estrogen, other menopause-related factors may also affect uric acid metabolism in postmenopausal females. Accordingly, we investigated factors related to increased serum urate levels in addition to lack of estrogen.

Subjects and methods: We studied 448 females who participated in an annual health check-up. None were being treated for gout, hyperuricemia, or diabetes mellitus, and no subjects had a history of hysterectomy and had never used estrogens or progestins. Body mass index (BMI), homeostasis model of insulin resistance (HOMA-R), and ethanol ingestion were investigated in all subjects, while information regarding menopause status was also obtained.

Results: Serum urate levels rose from the age of 46 to 60 years in the subjects. Multivariate regression analysis showed that BMI, HOMA-R, ethanol ingestion and menopause were independently associated with serum urate level. In addition, BMI and HOMA-R were higher in postmenopausal, as compared to premenopausal, subjects.

Conclusion: Our results suggest that menopause-related insulin resistance, obesity and ethanol ingestion as well as menopause may contribute to an increase in level of serum urate in postmenopausal Japanese women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aging / blood
  • Alcohol Drinking
  • Body Mass Index
  • Female
  • Homeostasis
  • Humans
  • Insulin Resistance
  • Japan
  • Middle Aged
  • Multivariate Analysis
  • Postmenopause / blood*
  • Regression Analysis
  • Uric Acid / blood*


  • Uric Acid