Enhancing immunity through autophagy

Annu Rev Immunol. 2009;27:423-49. doi: 10.1146/annurev.immunol.021908.132537.

Abstract

Next to the proteasome, autophagy is the main catabolic pathway for the degradation of cytoplasmic constituents. The immune system uses it both as an effector mechanism to clear intracellular pathogens and as a mechanism to monitor its products for evidence of pathogen invasion and cellular transformation. Because autophagy delivers intracellular material for lysosomal degradation, its products are primarily loaded onto MHC class II molecules and are able to stimulate CD4+ T cells. This process might shape the self-tolerance of the CD4+ T cell repertoire and stimulate CD4+ T cell responses against pathogens and tumors. Beyond antigen processing, autophagy's role in cell survival is to assist the clonal expansion of B and T cells for efficient adaptive immune responses. These immune-enhancing functions make autophagy an attractive target for therapeutic manipulation in human disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Autophagy / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Cytoplasm / immunology
  • Cytoplasm / metabolism
  • Histocompatibility Antigens Class II / immunology*
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Immune Tolerance
  • Immunity, Active
  • Immunity, Innate
  • Lysosomes / immunology
  • Lysosomes / metabolism
  • Phagosomes / immunology
  • Phagosomes / metabolism
  • Receptors, Tumor Necrosis Factor / immunology
  • Receptors, Tumor Necrosis Factor / metabolism

Substances

  • Cytokines
  • Histocompatibility Antigens Class II
  • Receptors, Tumor Necrosis Factor