Increasing incidence of fluoroquinolone-resistant Mycobacterium tuberculosis in Mumbai, India

Int J Tuberc Lung Dis. 2009 Jan;13(1):79-83.


Setting: Tertiary referral centre, private hospital, Mumbai, India.

Objective: To analyse the incidence of fluoroquinolone (FQ) resistant Mycobacterium tuberculosis (TB) in our laboratory from 1995 to 2004.

Design: Retrospective review and analysis of the drug susceptibility test records of all M. tuberculosis culture-positive samples from our Microbiology Department from 1995 to 2004.

Results: FQ resistance has increased exponentially in our laboratory, from 3% in 1996 to 35% in 2004. The incidence of multidrug-resistant tuberculosis has also increased during the same period, from 33% in 1995 to 56% in 2004.

Conclusion: The incidence of FQ-resistant M. tuberculosis is gradually increasing to alarming levels. This may be due to widespread use of this vital group of drugs in the treatment of community-acquired infections. We urge that these broad spectrum antibiotics be used judiciously, and ideally be reserved for treatment of resistant TB in TB-endemic areas.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Extensively Drug-Resistant Tuberculosis / epidemiology
  • Fluoroquinolones / pharmacology*
  • Humans
  • Incidence
  • India / epidemiology
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Tuberculosis, Multidrug-Resistant / epidemiology*
  • Urban Population / statistics & numerical data


  • Anti-Bacterial Agents
  • Fluoroquinolones