T-cell-mediated activation of macrophages

Curr Opin Immunol. 1991 Jun;3(3):330-5. doi: 10.1016/0952-7915(91)90033-w.


Functionally diverse subpopulations of macrophages and lymphocytes, a wide array of stimulatory signals, and an enormous effector repertoire of activated macrophages keeps this field dynamically active. We review new advances in the identification of cytokines that interact to activate macrophages, and in the discovery of effector molecules used by activated macrophages to destroy their targets.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / immunology
  • Granulocyte-Macrophage Colony-Stimulating Factor / immunology
  • Humans
  • Interleukin-2 / immunology
  • Interleukin-4 / immunology
  • Macrophage Activation / immunology*
  • Nitric Oxide / immunology
  • T-Lymphocytes / immunology*


  • Cytokines
  • Interleukin-2
  • Interleukin-4
  • Nitric Oxide
  • Granulocyte-Macrophage Colony-Stimulating Factor