[Atopic dermatitis aggravates the allergic airways inflammation in acute viral bronchiolitis]

Rev Mal Respir. 2008 Nov;25(9):1087-93. doi: 10.1016/s0761-8425(08)74978-7.
[Article in French]


Introduction: Exhaled nitric oxide (FeNO) is a putative non-invasive marker of eosinophilic airway inflammation with a good predictive value for allergic asthma in preschool children. The aim of the present study was to compare FeNO after acute viral bronchiolitis (AVB) in children aged less than 2 years without atopic dermatitis (AD) vs those with atopic dermatitis, as well as children with AD without any history of AVB.

Methods: Forty-two children (mean age +/- SD: 12.3 +/- 5.2 months; range 5.0-23.5; sex-ratio M: F=1.3: 1) were included in this prospective study, > 8 wks after an episode of AVB. The patients' atopic status was assessed both by clinical phenotype and IgE- mediated response to inhaled and/or food allergens. FeNO (ppb) was measured off-line by the chemoluminescence method on samples obtained from gas collected in a balloon during tidal breathing.

Results: There was a significant difference between the AVB/AD (23.4 +/- 14.3 ppb, n=15) vs the AVB without AD group (13.5 +/- 10. 1 ppb, n=13) or the AD without AVB group (11.0 +/- 8.3 ppb, n=14). Maternal feeding for more than 2 months decreased FeNO by 50%.

Conclusion: Atopic children below 2 years with AD produce more NO after AVB than non-atopic children or atopic children without any history of AVB. Maternal feeding decreases FeNO.

Publication types

  • English Abstract

MeSH terms

  • Acute Disease
  • Biomarkers / metabolism
  • Bronchiolitis, Viral / metabolism*
  • Cross-Sectional Studies
  • Dermatitis, Atopic / complications*
  • Female
  • Humans
  • Infant
  • Inflammation / metabolism
  • Male
  • Nitric Oxide / metabolism*
  • Pilot Projects
  • Prospective Studies


  • Biomarkers
  • Nitric Oxide