Subcutaneous phaeohyphomycosis caused by Exophiala xenobiotica in a non-Hodgkin lymphoma patient

Med Mycol. 2009 Feb;47(1):95-9. doi: 10.1080/13693780802526857. Epub 2008 Dec 19.

Abstract

Phaeohyphomycosis is a rare fungal infection that is more commonly associated with immunocompromised patients. We present a case in which a 77-year-old woman with non-Hodgkin lymphoma developed subcutaneous phaeohyphomycosis caused by Exophiala xenobiotica. E. xenobiotica is a dematiaceous hyphomycete that was recently identified as a segregant of the E. jeanselmei complex. The patient was successfully treated with local excision of the lesions and post-surgical oral itraconazole. The latter was administered with the aim of preventing systemic dissemination in this immunocompromised patient.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents / therapeutic use
  • DNA, Fungal / analysis
  • Dermatomycoses / drug therapy
  • Dermatomycoses / microbiology*
  • Dermatomycoses / pathology
  • Dermatomycoses / surgery
  • Exophiala / classification*
  • Exophiala / genetics
  • Exophiala / isolation & purification*
  • Female
  • Hand Dermatoses / drug therapy
  • Hand Dermatoses / microbiology*
  • Hand Dermatoses / pathology
  • Hand Dermatoses / surgery
  • Humans
  • Itraconazole / therapeutic use
  • Lymphoma, Non-Hodgkin / complications*
  • Sequence Analysis, DNA

Substances

  • Antifungal Agents
  • DNA, Fungal
  • Itraconazole