Antifungal susceptibility testing of Exophiala spp.: a head-to-head comparison of amphotericin B, itraconazole, posaconazole and voriconazole

Med Mycol. 2009 Feb;47(1):41-3. doi: 10.1080/13693780802512451. Epub 2008 Dec 12.

Abstract

Frequently, diseases caused by black yeasts are chronic in nature with a high morbidity. In addition, these infections are often fatal and relapse is common, even after prolonged treatment. Although the CLSI Document M38-A outlines methods for antifungal susceptibility testing of moulds, Exophiala spp. are not directly discussed. In an effort to determine the antifungal susceptibility patterns of Exophiala spp. we tested 160 clinical isolates against amphotericin B, itraconazole, posaconazole, and voriconazole in a head-to-head comparison. Posaconazole and itraconazole were the most active in vitro with MICs falling well below the achievable serum levels typically observed with standard dosing regimens.

Publication types

  • Comparative Study

MeSH terms

  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Exophiala / drug effects*
  • Exophiala / isolation & purification
  • Humans
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests* / methods
  • Microbial Sensitivity Tests* / standards
  • Mycoses / microbiology*
  • Pyrimidines / pharmacology
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • posaconazole
  • Amphotericin B
  • Voriconazole