Symmetry breaking: scaffold plays matchmaker for polarity signaling proteins

Curr Biol. 2008 Dec 23;18(24):R1130-2. doi: 10.1016/j.cub.2008.11.005.

Abstract

Many cell types can spontaneously polarize even in the absence of specific positional cues. In budding yeast, this symmetry-breaking polarization depends on a scaffold protein called Bem1p. A recent study defines Bem1p's molecular function during symmetry breaking.

MeSH terms

  • Adaptor Proteins, Signal Transducing / chemistry
  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Cell Polarity / physiology*
  • Guanine Nucleotide Exchange Factors / metabolism
  • Models, Biological
  • Protein Interaction Domains and Motifs
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / chemistry
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / chemistry
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / genetics
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / metabolism
  • p21-Activated Kinases / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Guanine Nucleotide Exchange Factors
  • Recombinant Fusion Proteins
  • Saccharomyces cerevisiae Proteins
  • BEM1 protein, S cerevisiae
  • p21-Activated Kinases
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae