Objective: To investigate a possible difference between true ovarian volume and ovarian volume estimated with two-dimensional (2D) transvaginal ultrasound.
Design: Prospective clinical and laboratory study.
Setting: University hospital research laboratory.
Patient(s): Premenopausal girls and women from three Danish national fertility centers (A: n = 42; B: n = 6; C: n = 18), who had one entire ovary removed for cryopreservation of ovarian cortex.
Intervention(s): Transvaginal 2D ultrasound measurement of ovarian volume before oophorectomy. True ovarian volume was obtained by weighing the ovary.
Main outcome measure(s): Ovarian volume estimated by weight and ultrasound.
Result(s): Ovarian tissue density was 1.00 g/mL. Mean ovarian volume by ultrasound vs. weight in the three groups was as follows: A: 6.3 mL vs. 7.8 mL; B: 5.4 mL vs. 6.8 mL; and C: 2.8 mL vs. 6.1 ml. Ovarian volume obtained by ultrasound was at least 27% smaller than the true ovarian volume.
Conclusion(s): Ovarian volume was severely underestimated by transvaginal 2D ultrasound measurement.
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.