Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates

Abstract

A new and simple protocol for the direct functionalisation of aldehydes with concomitant conversion into ketones via C-C bond formation has been developed. The reaction effectively enables the direct C-H activation of an aldehyde by mixing of an aldehyde and a vinyl sulfonate under aerobic conditions or using hydrogen peroxide as a sub-stoichiometric reagent.